Normally the reference to the imported hardware register file should be saved to the <mcu>.xml file in your project directory (see the EmbeddedProfileFile element in the .vgdbsettings file).
Please ensure that this file exists and is writable.
I re selected the SVD file in the hardware register window and a file named “STM32411xx.mcudef” is now in my project folder. That name also appears in “STM32.XML”. I am not sure what makes it “dissappear”, however in the past the hardware register window seems to “forget” this setting. I will try to monitor when it occurs.